Status:
RECRUITING
Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and Efficacy
Lead Sponsor:
University of Bonn
Conditions:
Rheumatic Diseases
Rheumatoid Arthritis (RA)
Eligibility:
All Genders
18+ years
Brief Summary
The CARe RAiSE project represents a pioneering translational initiative aimed at advancing precision medicine in the treatment of autoimmune rheumatic diseases. The primary objective is the developmen...
Detailed Description
Study Overview and Work Packages This study aims to functionally characterize individual immune responses in patients with autoimmune and autoinflammatory rheumatic diseases using immunological and m...
Eligibility Criteria
Inclusion
- Participants aged ≥ 18 years
- Signed written informed consent to participate voluntarily in the study.
- Confirmed diagnosis (by the treating physician) of one of the following autoimmune or autoinflammatory rheumatic diseases:
- Rheumatoid arthritis (RA)
- Psoriatic arthritis (PsA)
- Axial spondyloarthritis (axSpA)
- Giant cell arteritis (GCA)
- Connective tissue diseases, including:
- Systemic lupus erythematosus (SLE)
- Systemic sclerosis (SSc)
- Mixed connective tissue disease (MCTD)
- Idiopathic inflammatory myopathies (IIM)
- ANCA-associated vasculitides (AAV), including:
- Microscopic polyangiitis (MPA)
- Granulomatosis with polyangiitis (GPA)
- Eosinophilic granulomatosis with polyangiitis (EGPA)
- Autoinflammatory diseases, including
- Familial Mediterranean fever (FMF)
- Cryopyrin-associated periodic syndromes (CAPS)
- TNF receptor-associated periodic syndrome (TRAPS)
- Adult-onset Still's disease (AOSD)
Exclusion
- Refusal to participate in the study or inability to provide informed consent.
- Inclusion Criteria - Healthy Control Group:
- Participants aged ≥ 18 years (capable of providing informed consent).
- Signed written informed consent to participate voluntarily in the study.
- Exclusion Criteria - Healthy Control Group:
- \- Presence of a known or active rheumatologic disease.
Key Trial Info
Start Date :
April 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07150000
Start Date
April 1 2025
End Date
December 1 2028
Last Update
September 2 2025
Active Locations (1)
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1
University Hospital, Bonn
Bonn, North Rhine-Westphalia, Germany, 53127