Status:
NOT_YET_RECRUITING
Exploring Novel Biomarkers of ICU-AW in Mechanically Ventilated Children at the Molecular Level
Lead Sponsor:
Children's Hospital of Fudan University
Conditions:
ICU Acquired Weakness
Eligibility:
All Genders
1-18 years
Brief Summary
Acquired weakness (AW) is a common complication among patients in the Intensive Care Unit (ICU). It is a systemic muscle weakness and dysfunction associated with critical illness, often related to pro...
Detailed Description
An electronic database was established to collect clinical data from mechanically ventilated children, including baseline clinical characteristics, laboratory test results, and imaging data. Each part...
Eligibility Criteria
Inclusion
- Age between 28 days and 18 years;
- Patients continuously admitted to the PICU during the study period and subjected to invasive mechanical ventilation.
Exclusion
- Mechanical ventilation duration \< 72 hours;
- Presence of primary central or neuromuscular diseases that significantly affect central or peripheral respiratory failure, including: traumatic brain injury, cerebrovascular disease history (e.g., cerebral hemorrhage, cerebral infarction), intracranial tumors, central nervous system infections, spinal cord injury, Guillain-Barré syndrome, porphyria, paraneoplastic neuropathy, etc.;
- Conditions requiring immobilization such as limb joint surgery or fractures.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2028
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT07150650
Start Date
September 1 2025
End Date
September 30 2028
Last Update
September 2 2025
Active Locations (1)
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1
Children' hospital of Fudan university
Shanghai, Shanghai Municipality, China, 201102