Status:
RECRUITING
Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity
Lead Sponsor:
Ohio State University
Conditions:
Adequate Vitamin C Status
Inadequate Vitamin C Status
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity. Poor gut health-sometimes called "leaky gut"-can allow harmful subs...
Detailed Description
This clinical study aims to evaluate the impact of vitamin C supplementation on gut barrier function and systemic inflammation in adults with obesity. The research builds on preclinical findings that ...
Eligibility Criteria
Inclusion
- English speaking
- Men and women between 18-50 years of age
- BMI 30-40 kg/m²
- Resting blood pressure \<140/90 mm Hg
- No use of multivitamin/vitamin C supplement within past 1-month
- Non-vegetarian/non-vegan
- Willingness to follow a diet low in fruits and vegetables for two, 2-week periods
Exclusion
- Current smoker or vaper, including tobacco, cannabis, or nicotine products
- Alcohol consumption \>2 drinks/day
- Use of antibiotics within past 1-month
- Use of probiotic supplements within past 1-month
- Use of anti-inflammatory drugs within past 1-month
- Individuals with unmanaged or poorly controlled diabetes, dyslipidemia, hypertension
- Known history of bleeding disorders, hemochromatosis, or kidney stones
- For Women: Pregnancy, lactation, or change in birth control within the past 3-months
- Use of certain medications that may interact with vitamin C, including blood thinners, some antiviral drugs (e.g., indinavir), and certain antipsychotic medications (e.g., fluphenazine).
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT07151105
Start Date
October 1 2025
End Date
December 30 2026
Last Update
October 24 2025
Active Locations (1)
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1
The Ohio State University
Columbus, Ohio, United States, 43210