Status:
NOT_YET_RECRUITING
Protein Complementation of Plant-based Diets.
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Each Participant Will be Studied Over 5 Dietary Periods, Each Over 9d
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
Amino acids are the building blocks of proteins which are needed by the body for growth, and bodily functions. If even one amino acid is in short supply, this will negatively affect growth and various...
Detailed Description
Complementation of plant proteins with complementary amino acid profile (cereal grain + legume) in each meal can improve the protein quality of plant based diets. However, some maintain that if a vari...
Eligibility Criteria
Inclusion
- 1\) Young Adults:
- Adults, age 18 - 39 yrs, Healthy with no known clinical condition which would affect protein or AA metabolism, ex. Diabetes, Stable Body Weight (no more than 5 lb weight loss or gain in the past 3 months)
- Not on any medications that could affect protein or amino acid metabolism e.g. steroids.
- Fasting blood glucose, hemoglobin A1C (HbA1c), urea and creatinine within normal ranges for age.
- 2\) Older Adults:
- Adults, aged 60-69 and 70-79 years, Healthy with no known clinical condition which would affect protein or AA metabolism, ex. Diabetes, Stable Body Weight (no more than 5 lb weight loss or gain in the past 3 months)
- Not on any medications that could affect protein or amino acid metabolism e.g. steroids,
- Fasting blood glucose, hemoglobin A1C (HbA1c), urea and creatinine within normal ranges for age.
Exclusion
- Unwillingness to participate or unable to tolerate the diet
- Recent history of weight loss within the last 3 months or on a weight reducing diet Inability to tolerate study diets (ex. Allergy to ingredients).
- Significant caffeine consumption (\>2 cups per day)
- Significant alcohol consumption (\>1 drink per day i.e. 1 beer or ½ glass of wine).
- Fasting blood glucose, hemoglobin A1C (HbA1c), urea and creatinine outside of normal ranges for age.
- On medications known to affect protein and AA metabolism, renal failure, liver disease, unable to ambulate independently.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2029
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07151625
Start Date
October 1 2025
End Date
September 30 2029
Last Update
September 3 2025
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5S 1A8