Status:
RECRUITING
Use of Anodal tDCS to Enhance Upper Limb Recovery in Stroke
Lead Sponsor:
Tan Tock Seng Hospital
Collaborating Sponsors:
Ng Teng Fong Healthcare Innovation Programme
Conditions:
Stroke
Eligibility:
All Genders
21-80 years
Phase:
NA
Brief Summary
This will be a randomized, blinded, sham-controlled trial. The medical device used, Soterix Medical 1x1 tDCS stimulator, is capable of delivering either real or sham tDCS and has been used in many ran...
Detailed Description
The primary objective is to determine the clinical efficacy, technical feasibility and safety of anodal tDCS therapy to the unaffected hemisphere in hospitalized subacute stroke patients with severe a...
Eligibility Criteria
Inclusion
- First ever unilateral ischaemic or haemorrhagic stroke, as documented by CT or MRI scans
- Age 21-80 years, both males and females
- Within 8 weeks of stroke onset
- Severe weakness of one upper limb, defined by a Shoulder Abduction and Finger Extension (SAFE) score \< 5 (Medical Research Council grading)
- Provision of informed consent by patient or a legal guardian in accordance with the local ethics committee guidelines and the Declaration of Helsinki
Exclusion
- Bilateral hemispheric or cerebellar strokes
- Pre-existing arm pathology (e.g. contracture, severe pain, etc.) on the affected side
- Presence of brain implants, and previous insertion of external ventricular drains.
- Metallic implants at the level of the neck, mouth cavity and below are permitted (e.g. Cardiac stents, dental implants, pacemakers and other metallic objects)
- A history of spontaneous seizures, epilepsy, brain tumour, and cranial surgery
- Severe cognitive impairment (MOCA Score \<10) that would hinder sufficient understanding of the instructions
- Pregnancy
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07151729
Start Date
September 1 2025
End Date
December 31 2026
Last Update
September 3 2025
Active Locations (1)
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1
Tan Tock Seng Hospital - Integrated Care Hub
Singapore, Singapore, Singapore, 307382