Status:
RECRUITING
Thrombus Aspiration and Pathology and OCT Study
Lead Sponsor:
Fujita Health University
Collaborating Sponsors:
Fondazione IRCCS Policlinico San Matteo di Pavia
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
20+ years
Brief Summary
Most acute coronary syndromes (ACS) are caused by plaque complications triggering thrombotic events in the culprit plaques. Plaque complications include plaque rupture (Ruptured Fibrous Cap-RFC) with ...
Detailed Description
AIM Primary aim The present study aims to assess whether the composition of thrombus-aspirated material differs in samples retrieved from patients with OCT-described plaque rupture, erosion, or calcif...
Eligibility Criteria
Inclusion
- Patients with ACS showing ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) are studied.
- Only native coronary artery lesions are included in the study.
- Optical coherence tomography (OCT) was performed prospectively to compare OCT culprit lesions characteristics with histological analysis of athero-thrombotic aspirated material of the culprit lesion. For this purpose, only lesions with both athero-thrombotic aspirated material and OCT observations are included in the study.
- All patients provided written informed consent for the index procedure, follow-up, and anonymous data management.
Exclusion
- Patients are excluded from the study when they had cardiogenic shock and contraindications to anticoagulation and anti-platelet therapy.
- Lesions located in tortuous vessels, in ostial segment and in the left main stem are excluded from the study due to the difficulty in performing high-quality intracoronary imaging.
Key Trial Info
Start Date :
July 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07151976
Start Date
July 1 2016
End Date
December 31 2027
Last Update
September 3 2025
Active Locations (1)
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1
Fujita Health University
Toyoake, Aichi-ken, Japan, 470-1192