Status:
RECRUITING
Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy
Lead Sponsor:
Ain Shams University
Conditions:
Isoflurane
Sevoflurane
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
The primary aim of this work is to assess the impact of exposure to isoflurane or sevoflurane as an inhalation anesthetic on the oxidative stress and inflammatory conditions in patients undergoing ele...
Detailed Description
Oxidative stress is defined as "an imbalance between oxidants and antioxidants in favour of the oxidants, leading to a disruption of redox signalling and control and/or molecular damage. Isoflurane, ...
Eligibility Criteria
Inclusion
- Age from 20 to 60 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) Physical Status I-II.
- Undergoing elective laparoscopic cholecystectomy under general anesthesia.
Exclusion
- Refusal of participation in the study by patients.
- Diabetes (type I or II), endocrine system, and immune system diseases.
- Chronic infection and sepsis.
- Cardiac condition as classified bythe New York Heart Association (NYHA) \> class II.
- Hepatic disease: INR \> 1.5, and/or albumin \< 2.5 g/dL.
- Renal disease: glomerular filtration rate (GFR) \< 85 ml/min.
- Mental and neurological disorders.
Key Trial Info
Start Date :
September 4 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07152912
Start Date
September 4 2025
End Date
March 1 2026
Last Update
September 5 2025
Active Locations (1)
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1
Ain Shams University
Cairo, Egypt, 11591