Status:
RECRUITING
Efficacy of Perioperative Opioid Sparing Techniques on Time to Initiation of Chemotherapy
Lead Sponsor:
University of Tennessee Graduate School of Medicine
Conditions:
Perioperative Opioid Sparing Techniques
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The primary purpose of this study is to determine if intrathecal morphine (ITM) administration is superior to quadratus lumborum block or surgeon administered transversus abdominis plane (TAP) blocks ...
Detailed Description
Enhanced recovery after surgery (ERAS) has become the standard of perioperative care for patients undergoing oncologic surgery. Multimodal and regional anesthetic techniques to reduce postoperative pa...
Eligibility Criteria
Inclusion
- 18-80 years of age
- Patients undergoing open surgery for foregut, HPB, and colorectal cancer
- Able to read and understand study procedures
- Willing to participate and sign an ICF
- If female of childbearing potential, subject must have a negative pregnancy test
- Recommended for adjuvant chemotherapy
- Patients scheduled for an AM admit procedure
- English speaking
- Patients with a midline incision
Exclusion
- Chronic Opioid Use (received an opioid within 90 days preoperatively)
- Recreational Drug Use
- Patients with cognitive impairments that can affect their ability to give consent
- Patients that are currently taking anti-coagulants \<7 days prior to surgery
- Pregnant or breastfeeding
- Does not require adjuvant chemotherapy
- Relative Contradictions for receiving a nerve block\*
- Patients that have been admitted prior to surgery for chief complaint related to complications from malignancy
- Inability to provide consent
- Absolute Contraindications
- Lack of patient consent.
- Skin infection at the site of needle insertion. Relative Contraindications
- Coagulopathy
- Systemic infection
- Anatomical distortion
- Neuropathy
- Drugs/Device usage within 7 Days of Randomization if any:
- • Anticoagulants
Key Trial Info
Start Date :
February 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 3 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07153614
Start Date
February 3 2025
End Date
February 3 2027
Last Update
September 4 2025
Active Locations (1)
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1
University of Tennessee Graduate School of Medicine
Knoxville, Tennessee, United States, 37920