Status:
RECRUITING
Comprehensive Analysis of Gut Microbiota Signatures in Metastatic Colorectal Cancer
Lead Sponsor:
Sixth Affiliated Hospital, Sun Yat-sen University
Conditions:
Rectal Neoplasms
Colon Neoplasms
Eligibility:
All Genders
18-75 years
Brief Summary
Colorectal cancer (CRC) is one of the most common and deadly cancers worldwide. About 1 in 4 people with CRC already have cancer spread (metastasis) when first diagnosed, and about half develop spread...
Eligibility Criteria
Inclusion
- Age between 18 and 75 years
- Pathologically confirmed colorectal cancer
- Clearly defined clinical staging: including imaging or pathologically confirmed metastatic colorectal cancer (stage M1) and colorectal cancer without distant metastasis (stage M0)
- Expected survival ≥ 3 months
- Voluntary participation and signed informed consent
Exclusion
- Use of probiotics, antibiotics, or immunosuppressive agents within 1 month before surgery
- Preoperative complete intestinal obstruction or gastrointestinal perforation
- Intraoperative gastrointestinal perforation or tumor rupture
- Previous history of gastrointestinal surgery (excluding colorectal cancer surgery, appendectomy, and cholecystectomy) or concurrent severe gastrointestinal diseases such as inflammatory bowel disease
- Concurrent active systemic immune or infectious diseases, including severe allergies, rheumatoid arthritis, systemic lupus erythematosus, viral hepatitis, acquired immunodeficiency syndrome, etc.
- Concurrent unhealed primary malignant tumors
- Severe organ dysfunction or failure
- Other conditions deemed unsuitable for this study by the investigator
Key Trial Info
Start Date :
January 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT07154173
Start Date
January 1 2025
End Date
December 31 2026
Last Update
December 31 2025
Active Locations (1)
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1
The Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510655