Status:
NOT_YET_RECRUITING
Lymphocyte Function Testing in Immuno-oncology
Lead Sponsor:
Centre Leon Berard
Conditions:
Immunotherapy
Advanced Solid Tumor Malignancies
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Several studies have shown that the presence and levels of IFN-γ may correlate with better responses to immunotherapy. Higher baseline levels of IFN-γ and an increase in its production during treatmen...
Eligibility Criteria
Inclusion
- Male or female aged 18 years or older with a confirmed diagnosis of solid tumors (any type of tumor) in advanced or metastatic stages
- Patients who are due to start standard treatment with anti-PD1, anti-PDL1, or anti-CTLA4 (combinations of ICIs are permitted) at the Léon Bérard Center:
- Cohort A: ICI without concomitant chemotherapy
- Cohort B: ICI with concomitant chemotherapy
- Patients who have understood, dated, and signed the consent form for this study before undergoing any protocol-specific procedures.
- Patients affiliated with or covered by a social security system.
Exclusion
- Patients to be treated with immunotherapy in combination with targeted therapy.
- Patients treated with chemotherapy within the last 21 days prior to D1 of immunotherapy
- Pregnant or breastfeeding patients.
- Patients with other known cancers that are progressing or requiring the initiation of another treatment.
- Patients with psychological, family, geographical, or social circumstances that, in the investigator's judgment, could potentially prevent the signing of an informed consent form and/or compliance with study procedures.
- Patients in one or more of the following situations: subject to legal protection measures, deprived of liberty by judicial or administrative decision, receiving psychiatric care, admitted to a health or social care facility for purposes other than research
Key Trial Info
Start Date :
September 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 23 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT07155811
Start Date
September 23 2025
End Date
September 23 2025
Last Update
September 4 2025
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