Status:
RECRUITING
Impact of Plant Proteins and Exercise on Protein Metabolism in Older Adults
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborating Sponsors:
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Université d'Auvergne
Conditions:
Eldery People
Sedentarity
Eligibility:
MALE
65+ years
Phase:
NA
Brief Summary
To gain mechanistic insights by examining the impact of innovative plant-protein fibre products, physical activity interventions on digestibility, amino acid bioavailability and whole-body protein met...
Detailed Description
Objective : to examine splanchnic extraction (SE), peripheral amino acid (AA) bioavailability and utilization (protein retention) from innovative plant proteins products, and muscle signalling markers...
Eligibility Criteria
Inclusion
- BMI 22-30 kg/m²
- Inactive (\<150 minutes of moderate to vigorous physical activity per week and no regular resistance training),
- Covered by a social security system
- Agrees to undergo the study interventions (undirect calorimetry, functional tests, physical activity program)
Exclusion
- Hamilton HAD scale with a score \> 9
- Subject with a pathology or treatment (diabetic on insulin, corticosteroids \> 8 days, neuroleptics, anticoagulant, antiplatelet) judged by the investigator as incompatible with the study
- Subject with unstabilized thyroid dysfunction for at least 3 months
- Subject with unstabilized hypertension for at least 3 months
- Subject with a medical and/or surgical history judged by the investigator as incompatible with the trial
- More than 21 alcoholic drinks per week
- Heavy smoker (\>10 cigarettes/day)
- Currently participating in another intervention study
- Absence of informed consent
- Inability to participate in physical activity
- Allergy(ies) or refusal to consume one of the foods tested as part of the the study
- Allergy to local anesthetics
- Declared glaucoma
- Prostate hypertrophy
- Refusal to register in the national file of volunteers who participate in research involving human beings
- Subject in a period of exclusion from a previous study or having received a total amount of compensation greater than 6,000 euros over the 12 months preceding the start of the trial (after verification in the File of Volunteers for Research involving Human Beings)
- Patients under guardianship, curatorship, deprived of liberty or legal protection
- Subject with claustrophobia
Key Trial Info
Start Date :
August 26 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT07155824
Start Date
August 26 2025
End Date
February 1 2027
Last Update
September 4 2025
Active Locations (1)
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1
CHU de Clermont-Ferrand
Clermont-Ferrand, France, 63000