Status:
NOT_YET_RECRUITING
Asymmetrical High Flow Oxygen Versus Noninvasive Ventilation in Acute Hypercapnic Respiratory Failure
Lead Sponsor:
Unity Health Toronto
Conditions:
Acute Hypercapnic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
NIV is a life-saving treatment for people with breathing failure and carbon dioxide (CO2) retention. It helps remove this waste gas from the lungs and reduces the effort needed to breathe. However, th...
Eligibility Criteria
Inclusion
- Diagnosed with acute hypercapnic respiratory failure
- Admitted to the intensive care unit
- Being treated with either high-flow oxygen treatment or non-invasive ventilation
Exclusion
- Clinical instability - defined as the presence of one of the followings: respiratory rate \> 40 breaths/minute, SpO2 \< 80%, active broncho-pleural fistula, Glasgow Coma Scale \< 8, mean arterial pressure below 60 mmHg despite usage of vasopressors
- Requiring immediate need of endotracheal intubation, according to the judgement of the attending physician
- Contraindications of monitoring with electrical impedance tomography (e.g. pacemaker, chest wall burns wounds limiting electrode placement).
Key Trial Info
Start Date :
August 25 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT07157098
Start Date
August 25 2025
End Date
July 1 2026
Last Update
September 5 2025
Active Locations (1)
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1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B1W8