Status:
NOT_YET_RECRUITING
Impact of Sacubitril/Valsartan on LV Diastolic Function in HFrEF
Lead Sponsor:
Assiut University
Conditions:
Left Ventricular Diastolic Function
Eligibility:
All Genders
Brief Summary
This prospective cohort study evaluates the effects of six months of sacubitril/valsartan (ARNI) therapy on left ventricular diastolic function in patients with heart failure with reduced ejection fra...
Detailed Description
Heart failure remains a leading global health issue characterized by high morbidity and mortality, with a pronounced burden in Egypt due to younger patient age and prevalent comorbidities such as diab...
Eligibility Criteria
Inclusion
- Diagnosed with HFrEF (LVEF \< 35%)
- Able to tolerate and comply with ARNI therapy
- Patients on Guideline-Directed Medical Therapy (GDMT) for heart failure
Exclusion
- Patients with contraindication to ARNI therapy
- Patients with poor echocardiographic window
- Patients non-compliant with medication or follow-up
- Patients with mitral significant lesion or mitral prosthesis.
- Patients with atrial arrhythmia or on pacemaker
Key Trial Info
Start Date :
June 1 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT07157527
Start Date
June 1 2026
End Date
December 30 2027
Last Update
September 5 2025
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