Status:
RECRUITING
Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
West China Hospital
The Affiliated Hospital of Qingdao University
Conditions:
Liver Transplantation
Tranexamic Acid
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
We propose a multi-center randomized trial to test the primary hypothesis that tranexamic acid is superior to placebo on blood loss in adult orthotopic liver transplantation within the initial 24 hour...
Detailed Description
BACKGROUND Chronic liver disease and cirrhosis account for around 2 million deaths per year worldwide. Liver transplantation has evolved remarkably over the years to become the standard-of-care for en...
Eligibility Criteria
Inclusion
- consenting adults aged at least 18 years who are scheduled for allogeneic liver transplantation with general anesthesia.
- \-
Exclusion
- 1) History of arterial or venous thrombosis within 3 months; 2) Re-transplantation; 3) Known allergy to tranexamic acid; 4) Participation in potentially conflicting clinical trials; 5) Considered by the responsible surgeon or anesthesiologist to be unsuitable.
- \-
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
1546 Patients enrolled
Trial Details
Trial ID
NCT07157631
Start Date
November 1 2025
End Date
December 1 2027
Last Update
December 8 2025
Active Locations (1)
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1
Anesthesiology, Renji Hospital, Shanghai Jiao Tong university school of medicine.
Shanghai, Shanghai Municipality, China, 200123