Status:
NOT_YET_RECRUITING
Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III/IV Periodontitis
Lead Sponsor:
shaimaa hamdy
Conditions:
Periodontal Diseases
LDL Hyperlipoproteinemia
Eligibility:
All Genders
30-65 years
Brief Summary
Periodontitis is a chronic, multifactorial inflammatory disease primarily caused by dysbiotic plaque biofilms, characterized by the progressive destruction of the supporting structures of the teeth. I...
Detailed Description
Oxidative stress has emerged as a key pathogenic mechanism linking periodontal inflammation with systemic diseases. Among the oxidative stress-related biomarkers, oxidized low-density lipoprotein (oxL...
Eligibility Criteria
Inclusion
- For all participants (applies to both groups):
- Age 30-60 years.
- Systemically healthy (based on medical history and physician clearance, if needed).
- No history of periodontal treatment within the last 6 months.
Exclusion
- 1\. History of systemic diseases affecting periodontium (e.g., uncontrolled diabetes, autoimmune diseases, osteoporosis).
- 2\. Current or past diagnosis of Alzheimer's disease or other neurodegenerative disorders.
- 3\. Use of medications affecting periodontal status (e.g., immunosuppressants, long-term corticosteroids, anticonvulsants).
- 4\. Antibiotic or anti-inflammatory therapy within the past 3 months. 5. Current smokers or history of smoking in the past year.
Key Trial Info
Start Date :
September 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 15 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07157878
Start Date
September 15 2025
End Date
September 15 2025
Last Update
September 5 2025
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