Status:
NOT_YET_RECRUITING
Investigating the Safety and Regenerative Potential of MSC-Derived Secretome Combined With PRGF in Knee Osteoarthritis
Lead Sponsor:
University of the Punjab
Collaborating Sponsors:
Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore.
Conditions:
Osteoarthritis (OA)
Knee Injury
Eligibility:
All Genders
30-55 years
Phase:
EARLY_PHASE1
Brief Summary
This Phase I/II randomized clinical trial investigates the safety, feasibility, and early regenerative potential of intra-articular administration of mesenchymal stem cell (MSC)-derived secretome comb...
Detailed Description
Osteoarthritis (OA) is a chronic, degenerative joint disease characterized by progressive cartilage degradation, joint space narrowing, subchondral bone remodeling, inflammation, and pain that ultimat...
Eligibility Criteria
Inclusion
- Following is the inclusion criteria for the enrolment of patients affected with damaged cartilage in this study:
- Diagnosed with primary OA in one or both knees based on American College of Rheumatology criteria
- Grade I and II Arthritis
- Joint pain ≥ 20mm measured by visual analogue scale
- Age ranges from 30-55 years of age
- BMI 27.12 ± 4.38
- Patients with no previous surgical interventions to lower limb
- Willing to participate in the study
Exclusion
- • Secondary OA due to trauma, infection, rheumatoid arthritis, congenital disease or other inflammatory disorders of the knee
- Diagnosed with a systemic autoimmune disorder, immunodeficiency or coagulation disorder
- Had history of malignancy
- History of allergy or allergic constitution
- Pregnant or breastfeeding women.
Key Trial Info
Start Date :
December 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 11 2028
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT07157891
Start Date
December 10 2025
End Date
December 11 2028
Last Update
September 5 2025
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