Status:
RECRUITING
Refractory Breathlessness in COPD
Lead Sponsor:
Seoul National University
Conditions:
COPD
Eligibility:
All Genders
18-100 years
Brief Summary
This study aims to investigate the prognosis and clinical outcomes of patients with chronic obstructive pulmonary disease (COPD) who continue to experience refractory dyspnea despite treatment with lo...
Detailed Description
The study aims to identify actionable clinical factors and develop predictive models that can enhance personalized management approaches for patients with refractory dyspnea in COPD. This is a prospe...
Eligibility Criteria
Inclusion
- Adults (≥ 18 years) diagnosed with chronic obstructive pulmonary disease (COPD) according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2025 criteria:
- Presence of COPD risk factors (e.g., smoking history, occupational exposure, genetic predisposition).
- Typical symptoms such as dyspnea, cough, or sputum production.
- Post-bronchodilator FEV1/FVC \< 0.70.
- Regular outpatient follow-up at the respiratory clinic.
- Received LABA/LAMA combination therapy for at least 3 months prior to enrollment.
- Ability and willingness to provide written informed consent.
Exclusion
- Poor adherence to LABA/LAMA therapy (medication possession rate \< 50%) or refusal of treatment.
- Inability or unwillingness to comply with scheduled visits, examinations, or follow-up procedures.
- Presence of severe comorbid conditions expected to significantly affect prognosis, including:
- End-stage diseases with life expectancy \< 1 year.
- Terminal malignancies receiving hospice or palliative care.
- Any condition that, in the opinion of the investigator, would interfere with study participation or data reliability.
Key Trial Info
Start Date :
April 11 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2031
Estimated Enrollment :
730 Patients enrolled
Trial Details
Trial ID
NCT07160322
Start Date
April 11 2024
End Date
December 31 2031
Last Update
September 8 2025
Active Locations (1)
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1
Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center
Seoul, Seoul, South Korea, 07061