Status:
NOT_YET_RECRUITING
Cognitive-Motor Training for AD/ADRD Prevention
Lead Sponsor:
University of Illinois at Chicago
Conditions:
MCI
Aging
Eligibility:
All Genders
55-95 years
Phase:
NA
Brief Summary
Alzheimer's disease and related dementias (AD/ADRD) greatly affect memory and daily activities in older adults. Mild Cognitive Impairment (MCI) is an early stage of dementia, affecting about 17% of ol...
Detailed Description
Alzheimer's disease/Alzheimer's disease and related dementias (AD/ADRD) significantly impair cognitive function and the ability to perform activities of daily living in older adults. Mild Cognitive Im...
Eligibility Criteria
Inclusion
- Age: 55-90 years.
- No recent major surgery, bone fracture, or hospitalization (\< 3 months).
- Not on any sedative drugs.
- Can understand and communicate in English.
- Can walk without an assistive device for at least 1 block to ensure independent functioning.
- Identification of Mild Cognitive Impairment (MCI) based on Jak/Bondi criteria
- Visual acuity greater than or equal to 20/40 with or without corrective lenses to ensure intact vision.
Exclusion
- Participants will not proceed with the study if any of the following occurs at baseline measurement: 1) Heart Rate \>85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) \> 160 mmHg and/or diastolic blood pressure (DBP) \> 110 mmHg during resting.
- Unable to stand for 5 minutes without an assistive device and walk for 10 m without an assistive device
- Complaints of shortness of breath, or uncontrolled pain (more than 3 out of 10 on Visual Analogue Scale), or if pulse oxygen drops less than 92% on the six-minute walk test (for endurance) to ensure that the participant can effectively participate without discomfort or injury during testing and training.
- Exhibits difficulty understanding the study information.
- Self-reported history or presence of any neurological, musculoskeletal, cardiorespiratory, or systemic disorders that significantly impact mobility or the ability to walk independently (without an assistive device).
- Self-reported disability (with or without an assistive device) to ensure independent functioning.
- Uncontrolled (not under any medications) hypertension to avoid cardiovascular complications during testing/training.
- Weight \>220 lbs (harness weight threshold).
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2027
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT07160582
Start Date
October 1 2025
End Date
May 31 2027
Last Update
September 8 2025
Active Locations (1)
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1
University of Illinois at Chicago
Chicago, Illinois, United States, 60612