Status:
NOT_YET_RECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
Lead Sponsor:
Indiana University
Conditions:
Mitochondrial Energetics
Dietary Nitrate
Eligibility:
MALE
18-44 years
Phase:
NA
Brief Summary
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a ...
Detailed Description
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a ...
Eligibility Criteria
Inclusion
- Men age 18-44
- Above the minimum threshold of the IPAQ questionnaire
- Below the maximum threshold of the IPAQ questionnaire
Exclusion
- Men and women \<18 or \>44 years of age
- Unable to provide informed consent
- Known clotting disorder
- Previous history of deep vein thrombosis
- Injury to either leg resulting in reduced mobility in the previous year
- Currently dieting or weight instability for the past 3 months
- Epileptic
- Pacemaker or other implantable heart device
- Currently taking antibiotics
- Current smoker
- Stage II hypertension (resting blood pressure \>140/\>90)
- Previously undergone a revascularization procedure involving a vascular graft or stenting of the femoral or popliteal arteries
- Those taking phosphodiesterase inhibitors (e.g., Viagra), proton pump inhibitors, antacids, xanthine oxidase inhibitors, hormonal contraceptives or on hormone replacement therapy
- An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q. These exclusions include the following:
- If participant's doctor has ever said that he/she has a heart condition and that he/she should only do physical activity recommended by a doctor
- Pain in chest when doing physical activity
- In past month, chest pain when not doing physical activity
- If participant has ever lost balance because of dizziness or has ever lost consciousness
- Muscle, bone, or joint problem that could be made worse by physical activity
- Currently on prescribed drugs for blood pressure or heart condition.
- If the participant knows of any other reason he/she should not do physical activity.
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT07161973
Start Date
January 1 2026
End Date
December 31 2026
Last Update
December 22 2025
Active Locations (1)
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1
Indiana University Indianapolis
Indianapolis, Indiana, United States, 46202