Status:
NOT_YET_RECRUITING
Efficacy of Flurbiprofen Spray for Postoperative Sore Throat Following Double-Lumen Endobronchial Intubation
Lead Sponsor:
Kittitorn Supphapipat, MD
Conditions:
Post Operative Sore Throat
Hoarseness
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
The goal of this study is to evaluate whether topical flurbiprofen reduces the incidence and severity of postoperative sore throat (POST) and hoarseness in patients undergoing double-lumen tube (DLT) ...
Detailed Description
Postoperative sore throat (POST) is a common complication after general anesthesia involving airway manipulation, with reported incidence rates of up to 62%. It includes a spectrum of symptoms such as...
Eligibility Criteria
Inclusion
- Patient aged 20-80 years
- Undergoing elective thoracic surgery
- Requiring DLT intubation for lung separation
- ASA physical status classification I-III
- Able to communicate and understand the study
Exclusion
- Contraindications to use of flurbiprofen, including allergies to flurbiprofen or NSAIDs, active peptic ulcer/ hemorrhage, history of gastrointestinal bleeding or perforation, severe colitis, severe heart failure, chronic kidney disease (CKD) stage IV or end-stage kidney disease (ESRD), or liver failure
- Recent or recurrent upper respiratory tract infection
- History of sore throat or hoarseness within 1 month prior to surgery
- History of previous airway surgery
- Chronic pain conditions
- Pregnancy
- Withdrawal criteria
- Fail DLT intubation
- Inability to extubation at the end of surgery
Key Trial Info
Start Date :
September 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT07163429
Start Date
September 10 2025
End Date
June 30 2027
Last Update
September 15 2025
Active Locations (1)
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1
Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University
Chiang Mai, Mueang, Thailand, 50200