Status:
NOT_YET_RECRUITING
Neoadjuvant Chemotherapy Combined With Preoperative Radiotherapy for Locally Advanced Breast Cancer
Lead Sponsor:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-70 years
Phase:
NA
Brief Summary
Approximately 20% of breast cancer patients in our country are in the locally advanced stage. The relatively low overall survival rate, high recurrence rate and distant metastasis risk of these patien...
Detailed Description
Approximately one fifth of the patients in China have non-metastatic locally advanced breast cancer. Due to their relatively low overall survival rate, high recurrence rate, and risk of distant metast...
Eligibility Criteria
Inclusion
- The pathological diagnosis was invasive breast cancer.
- cT3-4, cN1-2, M0 (according to the 8th edition of the AJCC Cancer Staging Manual), molecular typing is Luminal type (HER2-) or triple-negative type. The volume of the primary lesion did not decrease by more than 50% after 2 cycles of neoadjuvant chemotherapy.
- Generally in good condition (KPS score \> 70), organ functions are tolerable, and there are no severe complications due to poor control.
- Acceptable for magnetic resonance imaging scan
- Have the conditions for follow-up
- Sign the informed consent form
Exclusion
- gestation period
- Simultaneous bilateral breast cancer
- History of chest wall radiotherapy
- Active connective tissue disease
- Inflammatory breast cancer
- Excessive breast volume (\>600ml), BMI \> 30
- diabetes
- Positive lymph nodes in the upper and lower regions of the clavicle and the internal mammary region
- Using immunotherapy drugs such as PD-1/PD-L1
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2032
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07164872
Start Date
October 1 2025
End Date
December 31 2032
Last Update
September 10 2025
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