Status:
COMPLETED
Propofol Dose-Finding for Colonoscope Insertion in Adult Patients
Lead Sponsor:
Kocaeli City Hospital
Conditions:
Effect of Drug
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of this prospective dose-finding study is to determine the ED50 of propofol required for successful colonoscope insertion in adult patients. The study is designed using Dixon's up-and-down seq...
Detailed Description
The procedure is performed by an experienced endoscopist. If, during passage of the colonoscope through the rectosigmoid junction, the patient moves, experiences pain, vocalizes, or if the MOAA/S scor...
Eligibility Criteria
Inclusion
- Patients who provided informed consent to participate
- Patients scheduled for colonoscopy
- ASA physical status I-III
- Male and female patients aged 18-65 years
Exclusion
- Patients who did not provide consent
- Known allergy to propofol
- Body weight \<40 kg
- Body mass index (BMI) \>30 kg/m²
- Presence of acute or chronic pain
- Chronic alcohol consumption
- Use of antipsychotic, antidepressant, or hypnotic medications
- Patients with obstructive sleep apnea syndrome (STOP-Bang score ≥3)
- Patients with known anorectal diseases such as hemorrhoids, anal fissure, or anal fistula
- History of oncological disease
- Uncontrolled hypertension (blood pressure \>180/110 mmHg)
- Severe hepatic or renal dysfunction
- Acute respiratory tract infection or other chronic respiratory disorders
- Patients with a history of colorectal surgery
Key Trial Info
Start Date :
September 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 15 2025
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT07166640
Start Date
September 12 2025
End Date
October 15 2025
Last Update
November 18 2025
Active Locations (1)
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1
University of Health Sciences Kocaeli City Hospital
Kocaeli, Izmit, Turkey (Türkiye), 41100