Status:
NOT_YET_RECRUITING
Evaluation of the Dialytic Clearance of the Combination of Peracillin and Tazobactam
Lead Sponsor:
University Hospital, Rouen
Conditions:
Sepsis
Severe Bacterial Infections
Eligibility:
All Genders
18+ years
Brief Summary
Severe bacterial infections, often responsible for sepsis and septic shock, are a major challenge in critical care: approximately 50% of patients are affected, with a mortality rate of up to 40%. Thei...
Detailed Description
Pip-taz is administered intravenously due to non-absorption via the oral route. It is weakly bound to plasma proteins (21%), inducing good clearance of extrarenal clearance (fraction extracted in 4 ho...
Eligibility Criteria
Inclusion
- Adult patient over 18 years of age;
- Patient admitted to intensive care with a prescription for cREV (CVVH (pre- or post-dilution (convection)), CVVHD (diffusion), CVVHDF);
- Diagnosed or suspected infection sensitive to the piperacillin-tazobactam combination administered by continuous infusion as part of the patient's standard care;
- Concomitant prescription of piperacillin-tazobactam and cREV;
- Patient affiliated with a social security scheme;
- Adult who has read and understood the information letter and has not expressed non-opposition. Due to the potential life-threatening emergency, if the patient is unable to express their non-opposition, the consent of a trusted person or, where applicable, relatives will be sought.
Exclusion
- Documented or suspected allergy to penicillins;
- Opposition from the patient or trusted person;
- Pregnant, childbirth, or breastfeeding woman;
- Minor patient;
- Person deprived of liberty by an administrative or judicial decision;
- Person placed under judicial protection, guardianship, or curatorship.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2028
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT07167524
Start Date
October 1 2025
End Date
April 1 2028
Last Update
September 11 2025
Active Locations (1)
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1
University Rouen Hospital
Rouen, France, 76031