Status:
NOT_YET_RECRUITING
Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular Relaxation
Lead Sponsor:
Clare Hayes-Bradley
Conditions:
Induction of Anaesthesia
Muscle Relaxants
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
After a patient is put to sleep, a breathing tube is often placed through the larynx (voice box) into the trachea (windpipe). To place a breathing tube requires the muscles of the jaw, voice box, and ...
Eligibility Criteria
Inclusion
- General anaesthesia utilising an arterial line and rocuronium at an approved study site hospital (WSLHD - Blacktown \& Mount Druitt hospitals)
- Expected procedure duration \>1.5 hours
- no contraindications to rocuronium neuromuscular blockade
- no contraindications to propofol TCI anaesthesia
Exclusion
- Unable to consent for themselves for procedure
- Need for hospital interpreter (not currently funded for research use)
- pregnancy or lactation
- BMI \> 50
- neuromuscular condition (e.g. affecting muscle or neuromuscular junction)
- renal failure (eGFR \<30)
- chronic liver failure diagnosis
- epilepsy or antiepileptics
- lithium
- Atrial Fibrillation/Aflutter (regular rhythm needed for cardiac output monitor)
- gentamicin administered before induction
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT07168252
Start Date
December 1 2025
End Date
December 31 2026
Last Update
November 25 2025
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