Status:
NOT_YET_RECRUITING
Transfusion Exchanges and Cognition in Sickle Cell Disease
Lead Sponsor:
Centre Hospitalier St Anne
Conditions:
Drepanocytosis
Chronic Neurological Deficiency
Eligibility:
All Genders
18+ years
Brief Summary
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed...
Detailed Description
DREPA-COG is a non-interventional, multicenter observational study investigating the effect of exchange transfusions on cognitive performance in adults with severe sickle cell disease (SS or Sβ0). Cog...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Adults (≥18 years) with severe sickle cell disease (SS or Sβ0).
- Enrolled in a regular monthly transfusion exchange program.
- Not institutionalized.
- No known dementia.
- No severe aphasia.
- Affiliated with or beneficiary of a social security system.
- Exclusion criteria:
- Insufficient mastery of spoken French.
- Severe comorbidities preventing short-term follow-up.
- Known psychiatric disorders.
- Participation in another clinical study with ongoing exclusion periods.
- Lack of adequate computer equipment (minimum 11-inch screen and internet connection).
- Vulnerable patients under legal protection (guardianship or curatorship).
Exclusion
Key Trial Info
Start Date :
December 3 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 2 2027
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT07168447
Start Date
December 3 2025
End Date
November 2 2027
Last Update
September 11 2025
Active Locations (6)
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1
Assistance Publique - Hôpitaux de Paris Hôpital Avicenne
Bobigny, Île-de-France Region, France, 93000
2
Hôpital Henri Mondor
Créteil, Île-de-France Region, France, 94000
3
Hôpital Kremlin-Bicêtre
Le Kremlin-Bicêtre, Île-de-France Region, France, 94 275
4
GHU Paris Psychiatrie et Neurosciences - Hôpital Sainte-Anne
Paris, Île-de-France Region, France, 75014