Status:
RECRUITING
Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients
Lead Sponsor:
ARH van Zanten, MD PhD
Collaborating Sponsors:
Danone Global Research & Innovation Center
Wageningen University and Research
Conditions:
Post-Intensive Care Syndrome (PICS)
Eligibility:
All Genders
18+ years
Brief Summary
Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple co...
Detailed Description
Yearly, more than 70.000 patients are admitted to the intensive care unit (ICU) in the Netherlands. Although survival rates from critical illness have improved over the last decades, still patients su...
Eligibility Criteria
Inclusion
- Age ≥ 18 years at time of ICU admission;
- Received invasive mechanical ventilation (IMV) or non-invasive ventilation (NIV) within 48 hours after ICU admission
- Expected duration of ventilatory support (IMV or NIV) of ≥48 hours during ICU stay.
Exclusion
- Concurrent participation in an intervention study with an anticipated therapeutic effect on PICS outcomes (physical functioning, cognitive functioning, or mental health status)
- Pre-admission diagnosis of a progressive neurological disease (e.g., Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, progressive forms of multiple sclerosis)
- Participants with neurological paralysis significantly affecting leg function (e.g., spinal cord injury, multiple sclerosis)
- Patients receiving palliative care, with a life expectancy of \<3 months (e.g., hospice care or equivalent)
- Patients who are moribund (i.e., in the final stages of a terminal illness, with imminent death expected)
- Anticipated logistical limitations during recovery phase (e.g., transfer to another hospital, no fixed abode).
Key Trial Info
Start Date :
October 13 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2028
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07170527
Start Date
October 13 2025
End Date
September 1 2028
Last Update
December 12 2025
Active Locations (1)
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1
Gelderse Vallei Hospital
Ede, Gelderland, Netherlands, 6716 RP