Status:
ENROLLING_BY_INVITATION
Microperimetry Changes in Retinal Function in Macular Disorders
Lead Sponsor:
University of Nottingham
Conditions:
Dry AMD
Diabetic Retinopathy (DR)
Eligibility:
All Genders
21+ years
Brief Summary
The purpose of this study is to measure precisely how sensitive the central part of the retina - the light-sensitive film at the back of the eye, is to light. We will use a special device called the M...
Eligibility Criteria
Inclusion
- A. Patients
- Inclusion Criteria:
- Adult age above 21 years old.
- Signed informed consent
- Visual acuity Log MAR 0.0 to 1.2
- Patients diagnosed with:
- Geographic atrophy (AMD).
- Diabetic without retinopathy, and minimal to moderate non-proliferative diabetic retinopathy (NPDR) with or without presence of macular oedema on optical coherence tomography (OCT)
- Control group of age matched participants without any retinal disease, glaucoma or optic nerve disease in either eye Patients willing to attend follow-up MP examinations. (This does not apply to normal controls who only require one attendance).
- Exclusion Criteria
- Moderate to severe cataract (over grade 2) or other cause of opaque optical media that will preclude adequate fundoscopy or MP assessment.
- Previous treatments in the eye with intravitreal therapies of anti-VEGFs or steroids within the previous 6 months, or macular laser photocoagulation
- Active vascular event in either eye any examination time.
- Participants who are unable/unwilling to provide consent
- Participants who are unable to read English fluently
- B. Normal Controls Inclusion Criteria
- Normal controls will include persons who are not diabetic, and do not have glaucoma, any retinal or optic nerve disease.
- Signed informed consent
- Adult age above 21 years old. No upper age limit.
- Visual acuity LogMAR \<0.2.
- Controls should be willing to attend once only.
- Exclusion criteria
- Moderate to severe cataract (over grade 2) or other cause of opaque optical media
- Previous treatments in the particular eye with intravitreal therapies of anti-VEGFs or steroids within the previous 6 months, or macular laser photocoagulation
- Active/previous vascular event in either eye e.g. retinal arterial or vein occlusion, ischaemic optic neuropathy, or glaucoma
- Persons with diabetes
- Participants who are unable to read English fluently
- Participants who are unable/unwilling to provide consent
Exclusion
Key Trial Info
Start Date :
April 4 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 30 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07170683
Start Date
April 4 2025
End Date
August 30 2026
Last Update
September 12 2025
Active Locations (1)
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1
Nottingham University Hospitals NHS Trust
Nottingham, Notts, United Kingdom, NG7 2UH