Status:
WITHDRAWN
The Effect of Blueberry Supplementation on Cognitive Functioning in Older Adults
Lead Sponsor:
Wageningen University
Conditions:
Cognitive Decline
Cognition Disorders in Old Age
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
In this randomized placebo controlled intervention study, the effect of 12 weeks of supplementation with either 150g whole blueberries, freeze-dried blueberry powder (dose equivalent to 150g berries) ...
Detailed Description
Dementia is a public health priority. The prevalence of dementia is rapidly increasing due to population ageing, posing a great social and economic impact on caregivers, families and society. This, in...
Eligibility Criteria
Inclusion
- Age ≥65y
- Overweight, body mass index ≥25 kg/m2
- Mild memory complaints, i.e. ≥22 points on the Cognitive Failure Questionnaire (CFQ) and reporting to have memory complaints and being hampered by these complaints
- No mild cognitive impairment, i.e. ≥26 points on the Montreal Cognitive Assessment (MoCA)
- Able to understand and perform the study procedures
Exclusion
- Body Mass Index (BMI) ≥35 kg/m2
- Current use of \>500 mg/day of acetylsalicylic acid
- Current use of antidepressants
- Current use of medication that affects inflammation (anti-inflammatory medication)
- Current or recent (\<1 month) use of berry supplements
- Current or recent (\<1 month) use of anti-inflammatory dietary supplements such as fish oil, quercetin, curcumin, resveratrol, and/or other flavonoids
- Current or recent (\<3 month) use of antibiotics.
- Berry consumption of more than 1 serving (150g) per week
- Not willing to quit anthocyanin-rich product consumption during the study period
- Allergy to berries/salicylates
- Having a current disease which interferes with the effect of berries/ freeze-dried berry powder and/or with the outcome measure (cognitive functioning), including diagnosis of dementia, psychiatric disorders, gastro-intestinal disease, diabetes, and cancer, as judged by a medical doctor
- Excessive alcohol consumption (on average \>21 glasses/week for men and \>14 glasses/week for women)
- Current participation in other scientific research
Key Trial Info
Start Date :
November 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT07170943
Start Date
November 1 2021
End Date
October 1 2022
Last Update
September 12 2025
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