Status:
NOT_YET_RECRUITING
This Study Aims to Clinically Assess and Radiographically Measure the Formed Dentin Bridge Over the Pulp, Utilizing Three-dimensional Imaging Following the Application of Nanohydroxyapatite Versus Biodentine After Selective Caries Removal Over One Year Follow-up
Lead Sponsor:
Cairo University
Conditions:
Deep Carious Lesions
Partial Caries Removal
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This clinical trial aims to evaluate dentin bridge formation over the pulp following selective caries removal in permanent teeth with deep carious lesions (ICDAS scores 4-6). A total of 50 patients wi...
Detailed Description
This randomized controlled clinical trial is designed to investigate the effectiveness of two bio-inductive materials-nanohydroxyapatite and Biodentine-in promoting dentin bridge formation following s...
Eligibility Criteria
Inclusion
- Patient-related criteria:
- Adult patients (age: 18-40 years) of both genders.
- Good oral hygiene.
- Willing to sign the informed consent.
- Cooperative patients who accept the follow-up period.
- Tooth-related criteria:
- Posterior permanent caries (ICDAS 4-6).
- Radiographically, caries is extending 50% of dentine with a radiopaque layer between the carious lesion and the pulp chamber.
- Sensible teeth according to the cold pulp test.
- Negative response in percussion test.
Exclusion
- Patient-related criteria:
- Allergy to any of the restorative materials.
- Patients undergoing orthodontic treatment with fixed appliances.
- Pregnant women.
- Patients with debilitating systemic diseases.
- Patient who frequently uses analgesics or any drugs that could mask the pain.
- Tooth-related criteria:
- Teeth with previous restorations.
- Spontaneous pain or prolonged pain (more than 15 s) after the sensitivity test (cold test), which would indicate irreversible pulpitis.
- Negative sensibility tests, periapical radiolucency, and sensitivity to axial or lateral percussion.
- Mobile teeth, indicating periodontal disease or trauma.
- External or internal resorption.
- Chipped teeth or Cuspal loss
Key Trial Info
Start Date :
June 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07171775
Start Date
June 1 2026
End Date
June 1 2027
Last Update
September 18 2025
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