Status:
RECRUITING
Head dOwn Position Before Endovascular Treatment for Large veSsel Occlusion (HOPES5)
Lead Sponsor:
General Hospital of Shenyang Military Region
Conditions:
Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Recent studies suggest that head-down positioning (HDP) intervention may improve outcomes in ischemic stroke. In the era of reperfusion therapy, a key protective strategy is to administer neuroprotect...
Eligibility Criteria
Inclusion
- Age ≥ 18 years;
- Patients with acute large vessel occlusion scheduled for endovascular thrombectomy within 24 hours of symptom onset;
- Baseline National Institute of Health Stroke Scale (NIHSS) ≥ 6;
- Expected waiting time from randomization to femoral artery puncture is more than 30 minutes;
- ASPECTS/pc-ASPECTS score ≥ 6 on baseline non-contrast CT or DWI;
- Modified Rankin Scale score before stroke onset ≤ 1;
- Signed informed consent by patient or their legally authorized representative.
Exclusion
- Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage;
- Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis;
- Severe hypertension before randomization (systolic blood pressure \>185 mmHg or diastolic blood pressure \>110 mmHg);
- Cardiac insufficiency (NYHA Class ≥II);
- Pregnancy, plan to get pregnant or during lactation;
- Patients at significant risk of aspiration (e.g., obvious nausea and vomiting);
- The estimated life expectancy is less than 6 months due to other serious diseases;
- Other conditions unsuitable for this clinical study assessed by researcher.
Key Trial Info
Start Date :
September 2 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2026
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT07172789
Start Date
September 2 2025
End Date
September 30 2026
Last Update
September 15 2025
Active Locations (1)
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1
Hui-Sheng Chen
Shenyang, None Selected, China, 110016