Status:
ACTIVE_NOT_RECRUITING
Non-Invasive MASLD Diagnosis & T2D Remission Biomarkers
Lead Sponsor:
Royal College of Surgeons in Ireland - Medical University of Bahrain
Collaborating Sponsors:
King Hamad University Hospital, Bahrain
King Faisal Specialist Hospital & Research Center
Conditions:
MASLD
T2DM (Type 2 Diabetes Mellitus)
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to prospectively develop and validate a non-invasive scoring system based on metabolic markers, proteomic, and transcriptomic profiles to accurately screen, dia...
Detailed Description
Metabolic dysfunction Associated Steatotic Liver Disease (MASLD), previously known as NonAlcoholic Fatty Liver Disease (NAFLD), is becoming the most common cause of liver disease in adults with the pa...
Eligibility Criteria
Inclusion
- Adult obese patients undergoing bariatric surgery in KHUH surgery department consented to be included in the study.
Exclusion
- Patients fail to complete the surgery due to intra-operative complications.
- Patients fail to retrieve liver biopsy sample from due to intra-operative difficulties.
- Patients with missing data pre-operatively
- Body Mass Index less than 30 kg/m2.
- Post-liver transplant patients
- Patients known to have any liver disease other than MASLD
- Patients with history of Alcohol Drinking.
Key Trial Info
Start Date :
January 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
163 Patients enrolled
Trial Details
Trial ID
NCT07172997
Start Date
January 1 2025
End Date
June 30 2027
Last Update
September 15 2025
Active Locations (2)
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1
Alhakeem Radiology Center
Manama, Manama, Bahrain, 2901
2
King Hamad University Hospital
Al Muharraq, Muharraq, Bahrain