Status:
RECRUITING
The Effect of Continuous Versus Intermittent Enteral Nutrition on Metabolic Outcomes in Critically Ill Patients
Lead Sponsor:
Gelderse Vallei Hospital
Collaborating Sponsors:
ZonMw: The Netherlands Organisation for Health Research and Development
Wageningen University and Research
Conditions:
Critical Illness
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this clinical trial is to investigate the effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill adult patients. The aim of this study is to: ...
Eligibility Criteria
Inclusion
- Age ≥18 years;
- Receiving or eligible to receive exclusively gastric tube feeding;
- Expected ICU stay ≥48 hours;
- Receiving or anticipated to receive invasive mechanical ventilation within 48 hours after ICU admission.
Exclusion
- The treating clinician considers participation in the study clinically contraindicated (e.g., change in feeding regimen, no possibility for placement of CGM on arms, not able to receive exclusive gastric tube feeding);
- Death is deemed to be imminent or inevitable during admission, and the attending doctor, patient, or substitute decision-maker is not committed to active treatment;
- Pregnancy;
- Expected fasting for ≥12 hours during the study period, for example, due to medical procedures;
- Readmission in last 14 days;
- Patients with burn injuries;
- Participating in another nutritional intervention study.
Key Trial Info
Start Date :
September 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2028
Estimated Enrollment :
124 Patients enrolled
Trial Details
Trial ID
NCT07173504
Start Date
September 30 2025
End Date
September 1 2028
Last Update
October 6 2025
Active Locations (2)
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1
Gelderse Vallei Hospital
Ede, Gelderland, Netherlands, 6716 RP
2
Martini Ziekenhuis
Groningen, Provincie Groningen, Netherlands, 9728NT