Status:
NOT_YET_RECRUITING
Innovative Approaches to Enhance Balance and Neuroplasticity in Multiple Sclerosis
Lead Sponsor:
University Health Network, Toronto
Collaborating Sponsors:
Direct MS Canada
Conditions:
Multiple Sclerosis
Mobility Limitation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This study will evaluate the effects of combining balance training with electrical stimulation techniques in individuals with Multiple Sclerosis (MS). MS commonly impairs leg strength, coordination, a...
Eligibility Criteria
Inclusion
- Participants will be eligible if they meet the following conditions:
- Confirmed diagnosis of Multiple Sclerosis (MS) according to the revised McDonald criteria
- Age ≤ 65 years
- Ability to walk at least 100 meters, with or without an assistive device, and without requiring rest
- Self-reported perception of impaired balance during standing or walking in daily activities
- Exclusion Criteria:
- Participants will be excluded if they present with any of the following:
- Uncorrected visual problems
- Cognitive impairment affecting comprehension of instructions or completion of self-administered outcome measures
- Ongoing MS exacerbation or paroxysmal vertigo
- Concurrent neurological or orthopedic conditions affecting balance
- Recent participation in rehabilitation therapies (physical therapy, occupational therapy, or vestibular therapy) within one month prior to recruitment
- Planned or recent injection of botulinum toxin to the legs during the intervention period
- Peripheral nerve damage affecting the legs
- Contraindications to electrical stimulation, including:implanted electronic device, active cancer or radiation treatment within the past 6 months, uncontrolled epilepsy, skin rash or open wound at electrode site, pregnancy, active deep vein thrombosis
Exclusion
Key Trial Info
Start Date :
October 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2028
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT07174973
Start Date
October 30 2025
End Date
December 30 2028
Last Update
September 16 2025
Active Locations (1)
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1
Toronto Rehabilitation Institute
Toronto, Ontario, Canada