Status:

NOT_YET_RECRUITING

Prevalence of Translocation Phenotyping in Children With Down Syndrome and Their Parents

Lead Sponsor:

Assiut University

Conditions:

Translocation Down Syndrome

Chromosomal Abnormalities

Eligibility:

All Genders

1-18 years

Brief Summary

This research study will investigate a special type of Down syndrome called translocation Down syndrome. While most children with Down syndrome have an extra copy of chromosome 21, about 3-4% have thi...

Detailed Description

Down syndrome (DS) is the most common chromosomal disorder, occurring in approximately 1 in 700 live births worldwide, and is associated with intellectual disability and multiple congenital anomalies....

Eligibility Criteria

Inclusion

  • Children aged 0-18 years with confirmed diagnosis of Down syndrome by chromosomal analysis.
  • Availability of at least one biological parent willing to undergo chromosomal analysis.

Exclusion

  • Children with Down syndrome due to free trisomy 21 or mosaicism.
  • Incomplete parental data or refusal of parental participation.

Key Trial Info

Start Date :

October 1 2025

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 1 2026

Estimated Enrollment :

230 Patients enrolled

Trial Details

Trial ID

NCT07175168

Start Date

October 1 2025

End Date

December 1 2026

Last Update

September 16 2025

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