Status:
NOT_YET_RECRUITING
Dexmedetomidine as an Adjunct to Periarticular Ropivacaine in Total Knee Replacement: A Pilot Randomised Controlled Trial
Lead Sponsor:
University of Malaya
Conditions:
Postoperative Pain Management in Total Knee Arthroplasty
Eligibility:
All Genders
18-100 years
Phase:
PHASE4
Brief Summary
This study aims to evaluate whether adding dexmedetomidine to ropivacaine-based periarticular infiltration (PAI) improves postoperative pain control in patients undergoing total knee replacement (TKR)...
Detailed Description
Total knee replacement is associated with significant postoperative pain despite the use of multimodal analgesia. Periarticular infiltration (PAI) using local anaesthetics such as ropivacaine has beco...
Eligibility Criteria
Inclusion
- Aged ≥18 years
- Undergoing elective unilateral total knee replacement
- ASA physical status I-III
- No known allergy to local anaesthetics or dexmedetomidine
- No opioid use \>24 hours preoperatively
- Provided informed consent
Exclusion
- Known allergy to study drugs
- Chronic pain or neurological conditions
- Bilateral or revision TKR
- Significant deformity affecting function
- Substance abuse history
- Day-case surgery
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT07176065
Start Date
October 1 2025
End Date
December 1 2028
Last Update
September 16 2025
Active Locations (1)
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1
Universiti Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, Malaysia, 59100