Status:
RECRUITING
Exploring Blood Cell Function and Oxidative Stress to Improve Diagnosis and Treatment in Pre-Capillary Pulmonary Hypertension
Lead Sponsor:
University Hospital, Strasbourg, France
Conditions:
Pre-capillary Pulmonary Hypertension
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to understand how blood cell (including peripheral blood mononuclear cells ((PBMCs) or platelets) function and oxidative stress can help physicians detect and predict the course of pre...
Eligibility Criteria
Inclusion
- Adult patients (≥18 years) diagnosed with pre-capillary pulmonary hypertension confirmed by right heart catheterization
- Patients classified according to the international clinical classification:
- Group 1: Pulmonary arterial hypertension (PAH)
- Group 3: Pulmonary hypertension associated with chronic respiratory diseases and/or hypoxia
- Group 4: Chronic thromboembolic pulmonary hypertension (CTEPH)
- Patients scheduled for routine clinical follow-up and/or right heart catheterization at the study center.
- Ability and willingness to provide informed consent for participation and data analysis.
Exclusion
- Postcapillary pulmonary hypertension (pulmonary arterial wedge pressure \>15 mmHg).
- Conditions precluding safe blood sampling (e.g., severe anemia, coagulopathy).
- Patients already enrolled in interventional clinical trials that could interfere with mitochondrial or oxidative stress measurements
- Patients unable or unwilling to provide informed consent
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07176260
Start Date
September 1 2025
End Date
June 1 2026
Last Update
September 16 2025
Active Locations (1)
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1
Hôpitaux Universitaires de Strasbourg - Service Physiologie explorations fonctionnelles
Strasbourg, Bas-Rhin, France, 67000