Status:
NOT_YET_RECRUITING
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
Lead Sponsor:
University Hospital Ostrava
Conditions:
Prolonged Mechanical Ventilation
Critical Illness
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel obje...
Detailed Description
More than 95% of serum creatinine comes from skeletal muscles, where it is formed by non-enzymatic degradation of creatine. Therefore, in patients with normal kidney function, the serum creatinine val...
Eligibility Criteria
Inclusion
- Patients \<18 years of age
- Patients admitted to post-ICU care units at Chronicare Group a.s. in the Czech Republic within 12 months
Exclusion
- Patients who are unlikely to be weaned from ventilatory support.
- Patients in palliative care or with a survival probability of \<3 months
- Patients with advanced malignancy
- Patients with a history of chronic kidney disease
- Patients with a history of chronic liver disease
- Patients with supranormal serum creatinine on admission to the post-ICU care unit
- Patients who refused to sign the Informed Consent with participation in the study.
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
492 Patients enrolled
Trial Details
Trial ID
NCT07177183
Start Date
October 1 2025
End Date
December 31 2026
Last Update
September 16 2025
Active Locations (4)
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1
Chronicare Mund s.r.o.
Brno, Czechia, 621 00
2
Chronicare Mund s.r.o.
Brno, Czechia, 639 00
3
Chronicare s.r.o.
Milovice, Czechia, 289 24
4
Chronicare Nord s.r.o.
Ostrava, Czechia, 700 30