Status:
NOT_YET_RECRUITING
The Effect of a Protective Oral Care Protocol Using Peppermint Oil Mouthwash
Lead Sponsor:
Şule Güzle
Conditions:
Hematologic Neoplasms
Nausea
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Hematologic malignancies are the fifth most common type of cancer in the world. Patients with hematologic malignancies receive long-term and exhausting treatments such as chemotherapy, radiotherapy, h...
Detailed Description
Background: Hematologic malignancies are a group of neoplasms caused by the uncontrolled proliferation of cells in lymphoid tissue or bone marrow. Hematologic malignancies are considered the fifth mos...
Eligibility Criteria
Inclusion
- Age 18 years or older
- Clinical diagnosis of hematologic malignancy
- History of at least one chemotherapy cycle
- Scheduled to receive chemotherapy with high or moderate emetogenic risk agents
- No oral mucositis before chemotherapy
- No metastasis
- Literate (able to read and write)
- Volunteer to participate in the study
Exclusion
- Use of herbal remedies for nausea, vomiting, or anorexia
- Concurrent radiotherapy with chemotherapy
- Non-adherence to standard antiemetic therapy according to the chemotherapy preparation regimen and protocol (e.g., use of antiemetics other than granisetron or metoclopramide)
- Known allergy to peppermint oil
- Psychiatric disorders
- Communication impairments (hearing or speech difficulties)
- Altered level of consciousness
- Endotracheal intubation
- Requirement for oral care solutions other than the clinic's routine procedures (saline or sodium bicarbonate)
- Chronic gastrointestinal diseases (gastritis, gastric/peptic ulcer, ulcerative colitis, Crohn's disease, gastroesophageal reflux, irritable bowel syndrome, cirrhosis, or pancreatitis)
- Migraine
- Brain metastases
- Hepatic or renal insufficiency
- Administration of low-emetogenic chemotherapy
- Mucositis (Oral Assessment Guide score: 15-24 points)
Key Trial Info
Start Date :
September 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 10 2026
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT07179094
Start Date
September 10 2025
End Date
June 10 2026
Last Update
September 17 2025
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