Status:
RECRUITING
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
University of Leicester
Conditions:
Cerebral Autoregulation
Blood Pressure
Eligibility:
All Genders
65-85 years
Phase:
NA
Brief Summary
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically. Recent findings have demonsatrated efficacy ...
Detailed Description
Remote Ischaemic Conditioning (RIC) involves the delivery of short periods of ischaemia to a limb (using a blood pressure cuff), with the aim of promoting resilience to ischaemia in distant organs. It...
Eligibility Criteria
Inclusion
- Participant is willing and able to give informed consent for participation in the study
- Participant aged 65 - 85
- Participant is able to perform RIC independently at home
Exclusion
- Active cardiovascular or cerebrovascular disease (acute event within the last 12 months)
- Atrial fibrillation or other significant arrhythmias
- Peripheral Vascular Disease
- Haemostatic disorders
- Soft tissue injury or fracture to the upper limb
- Pregnant or breast feeding
- History or current psychiatric illness
- History or current neurological condition (e.g. epilepsy)
- Inability to identify temporal window for transcranial doppler ultrasound at screening visit
- Any condition or presentation under current investigation that is deemed by the study clinician to exclude the participant from the study.
- Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Key Trial Info
Start Date :
August 27 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2027
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT07179887
Start Date
August 27 2025
End Date
September 30 2027
Last Update
September 18 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
School of Medicine, University of Nottingham, Royal Derby Hospital Centre
Derby, Derbyshire, United Kingdom, DE22 3DT