Status:
ACTIVE_NOT_RECRUITING
Upfront Neck Dissection Before Radiotherapy in Stage N3 Nasopharyngeal Carcinoma: A Retrospective Study
Lead Sponsor:
Taichung Veterans General Hospital
Conditions:
Oncology
Radiology
Eligibility:
All Genders
18+ years
Brief Summary
This retrospective observational study aims to evaluate the association between neck tumor burden and high-risk imaging features with locoregional recurrence and distant metastasis in patients with st...
Detailed Description
Nasopharyngeal carcinoma (NPC), due to its anatomical proximity to the skull base and critical cervical structures, is primarily treated with radiotherapy. However, even with current standard treatmen...
Eligibility Criteria
Inclusion
- Age ≥ 18 years.
- Pathologically confirmed diagnosis of nasopharyngeal carcinoma (NPC).
- Stage IV disease (Tany N3) according to the 8th edition of the AJCC staging system.
- Completion of definitive concurrent chemoradiotherapy (CCRT), or induction chemotherapy (IC) followed by radiotherapy/CCRT.
- Availability of complete clinical imaging and medical records before and after treatment for efficacy and prognostic analysis.
Exclusion
- Presence of distant metastasis at initial diagnosis.
- Prior history of treatment for other head and neck malignancies, aside from definitive therapy for NPC (to avoid confounding prognosis).
- Incomplete or prematurely discontinued definitive radiotherapy, resulting in failure to complete the planned curative treatment.
- Lack of complete pathology report, clinical imaging, or treatment records, making effective analysis impossible.
Key Trial Info
Start Date :
November 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 29 2026
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT07180173
Start Date
November 1 2022
End Date
September 29 2026
Last Update
September 18 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Taichung Veterans General Hospital
Taichung, Taiwan