Status:
COMPLETED
Predicting Pathological Complete Response in Esophageal Squamous Cell Carcinoma Using a Multimodal Model Integrating Clinical, Radiomics, and Deep Learning Features
Lead Sponsor:
Nanjing Medical University
Collaborating Sponsors:
The Affiliated cancer hospital of Nanjing Medical University
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Esophageal Squamous Cell Carcinoma
Pathological Complete Response
Eligibility:
All Genders
18+ years
Brief Summary
This multicenter, retrospective cohort study reviews the medical records and CT scans of adults with esophageal squamous cell carcinoma (ESCC) who received neoadjuvant immunotherapy plus chemotherapy ...
Detailed Description
Design and Setting. Multicenter, retrospective cohort study conducted at three affiliated hospitals in China. A total of 363 consecutive ESCC patients met eligibility criteria and were split into a tr...
Eligibility Criteria
Inclusion
- Biopsy-confirmed esophageal squamous cell carcinoma (ESCC). Locally advanced disease per AJCC 8th ed. (cT1N1-T3N0-3M0) on contrast-enhanced CT.
- Completed standardized neoadjuvant chemo-immunotherapy (e.g., paclitaxel + cisplatin/carboplatin with camrelizumab every 2-3 weeks) prior to surgery.
- High-quality venous-phase chest CT (slice thickness ≤5 mm) obtained within 14 days before therapy start.
- Underwent R0 resection 6-8 weeks after therapy. Availability of a definitive postoperative pathology report to ascertain pCR status.
Exclusion
- Non-squamous histology; distant metastasis (M1); synchronous malignancies. Inadequate imaging quality (no venous phase, slice thickness \>5 mm, severe artifacts, or incomplete tumor visualization).
- Did not complete the full treatment course or had missing endpoints (e.g., no pathological response record or lost to follow-up).
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2025
Estimated Enrollment :
363 Patients enrolled
Trial Details
Trial ID
NCT07181850
Start Date
January 1 2019
End Date
July 31 2025
Last Update
September 18 2025
Active Locations (1)
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1
The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University
Huai'an, Jiangsu, China, 223000