Status:
NOT_YET_RECRUITING
Fatigue in MS: From Invisible to Measurable
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
UHasselt
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-60 years
Brief Summary
Fatigue is one of the most common and burdensome symptoms of MS, but its precise cause remains unknown, and an effective treatment is lacking. Previous research has shown that the progression of MS is...
Detailed Description
Forty individuals with MS will be asked to complete questionnaires about fatigue and perform motor tasks. Additionally, blood samples will be taken to measure the levels of cytotoxic CD4+ T-cells. The...
Eligibility Criteria
Inclusion
- Diagnosis of relapsing remittion, primary progressive or secondary progressive MS
- Age: 18-60 years
- Ability to perform the foot-tapping task
- Ability to walk at least 20 meters (with or without walking aid)
Exclusion
- Dimethyl fumarate, fingolimod or alemtuzumab treatment, since these medications have a strong influence on the immune system As a result of these treatments, there are few to no immune cells circulating in the blood, meaning we cannot find our population of interest in the blood.
- Change in medication 6 weeks before the start of the study (including medication not related to MS) - MS relapse within 6 weeks of the start of the study
- Had an infection in the last month - Received a vaccination in the last 14 days - Pregnant or pregnancy in the last 6 months
- Having a psychiatric disorder
- Having a neurological disorder other than MS
- Having cognitive or communicative problems that makes it hard to follow instructions
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07182903
Start Date
October 1 2025
End Date
December 31 2025
Last Update
September 19 2025
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