Status:
RECRUITING
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
Lead Sponsor:
University of Virginia
Conditions:
MINOCA
Shortness of Breath
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive...
Detailed Description
The overall research plan is for 25 subjects with angina and no obstructive coronary artery disease (ANOCA) on invasive or coronary CT angiography (ANOCA Study Population) to undergo cardiopulmonary e...
Eligibility Criteria
Inclusion
- Age 18-85
- ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
- Able to use the wearable and participate in a remote exercise program
- Able to participate in intermittent high-intensity training.
- Able to perform cardiopulmonary exercise testing (CPET)
- Able to provide Health-related quality of life questionnaire (HRQOL)
- Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English
Exclusion
- Systolic heart failure (LVEF \<50% or NYHA class III symptoms)
- Prior myocardial infarction, coronary revascularization
- Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
- Pregnancy (due to unknown effects on CPET exercise markers)
- Inability to provide informed consent
- Life expectancy \<1 year
- Prisoners
- Cognitively impaired
- Non-English speaking
Key Trial Info
Start Date :
August 11 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 14 2026
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT07182955
Start Date
August 11 2025
End Date
April 14 2026
Last Update
September 19 2025
Active Locations (1)
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1
University of Virginia Health System
Charlottesville, Virginia, United States, 22908