Status:
ENROLLING_BY_INVITATION
Exploratory Trial of VR Intervention on Neuroplasticity in Older Adults With Cognitive Frailty
Lead Sponsor:
Peking Union Medical College
Conditions:
Cognitive Frailty
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
To investigate the effects of VR based intervention on neuroplasticity in older adults with cognitive frailty.
Detailed Description
This study is designed as a prospective, parallel-group, single-blind randomized controlled trial to be conducted at a senior care institution in Beijing from August to September 2025. Older adults wi...
Eligibility Criteria
Inclusion
- Frailty Phenotype (FP) score between 1 and 5
- Subjective Cognitive Decline Questionnaire (SCD-Q9) score ≥ 5
- Montreal Cognitive Assessment (MoCA) score between 15 and 25
- Activities of Daily Living (ADL) score ≤ 26
- Age ≥ 60 years
- Submit written informed consent prior to participating in the study
Exclusion
- Clinical diagnosis of Alzheimer's disease, other dementias, or neuropsychiatric disorders (e.g., cerebrovascular disease, Parkinson's disease, history of traumatic brain injury, brain tumors, epilepsy)
- Current use of medications or addictive substances that may impair cognition
- Presence of musculoskeletal disorders (e.g., osteoarthritis, fractures), cardiovascular disease, or liver/kidney dysfunction that prevent safe participation in exercise
- Severe sensory or speech impairments that hinder communication
- Severe motion sickness or vestibular disorders
Key Trial Info
Start Date :
July 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT07183033
Start Date
July 21 2025
End Date
December 31 2025
Last Update
September 19 2025
Active Locations (1)
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1
School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, Beijing Municipality, China, 100144