Status:
RECRUITING
Determination of the Prevalence of Unrecognized Heart Failure Among Patients at Risk in Urban Areas Across Germany Using CMR
Lead Sponsor:
German Heart Institute
Collaborating Sponsors:
Medical Statistics, University Medicine of Goettingen
AstraZeneca
Conditions:
Heart Failure With Preserved Ejection Fraction (HFPEF)
Eligibility:
All Genders
40-69 years
Brief Summary
Heart failure (HF) in patients at risk is often overlooked, and when detected, there is a lack of early and effective preventive interventions. The WE-CARE-HF-CMR study, conducted in large cities/metr...
Detailed Description
The WE-CARE-HF-CMR-study is a cross-sectional, nationwide prospective, community-based observational study to improve the diagnosis of heart failure in urban populations with characteristic risk facto...
Eligibility Criteria
Inclusion
- Asymptomatic subjects with:
- chronic diabetes mellitus (known/diagnosed and/or antidiabetic medication and/or elevated HbA1C) and/or
- renal impairment (known/diagnosed CKD and/or in laboratory CKD III° or higher) and/or
- Hypertension (known/diagnosed and/or antihypertensive medication/treatment) and/or
- Hypercholesterolaemia (known/diagnosed and/or antilipid medication/treatment) and/or
- Obesity (known/diagnosed and/or BMI \> 30 (kg/m²)) and/or
- Smoker (known/diagnosed and/or current/previous and/or medication/treatment)
- Age 40-69 years
- female or male or diverse sex
- Ability to provide informed consent
- Provision of Informed Consent
Exclusion
- Inability to provide written informed consent
- Diagnosed heart failure or previously detected reduced ejection fraction
- General MRI exclusion criteria (pacemaker, defibrillator, intracranial aneurysm clips, metallic foreign bodies in the eyes)
- Any MRI exclusion criteria not listed here, as determined by the MRI laboratory performing the procedure
- Haemodynamically unstable participants (heart rate \< 45/min, systolic blood pressure \< 90 mmHg)
- Claustrophobia
- Sensorineural hearing loss of 30 dB or more and tinnitus
- Acute mental disorders requiring therapy
- In the presence of pregnancy
Key Trial Info
Start Date :
September 13 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2035
Estimated Enrollment :
450 Patients enrolled
Trial Details
Trial ID
NCT07185100
Start Date
September 13 2025
End Date
December 31 2035
Last Update
September 22 2025
Active Locations (1)
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1
Deutsches Herzzentrum der Charité
Berlin, Germany, 13353