Status:
RECRUITING
Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions
Lead Sponsor:
Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Conditions:
Infertility
Eligibility:
FEMALE
20-40 years
Phase:
NA
Brief Summary
This study aims to evaluate the efficacy of atosiban in patients with previous pregnancy failure and abnormal uterine contractions during the peri-embryo transfer period in assisted reproductive techn...
Eligibility Criteria
Inclusion
- Participants/eligibility criteria
- Infertile women who fulfill all of the following inclusion criteria, based on the results and findings of the Atosiban 1 study are eligible for participation:
- Scheduled for single blastocyst-stage embryo transfer, either in a fresh or frozen transfer cycle;
- Have a history of one or more episodes of implantation failures in previous embryo transfer cycles;
- Age between 20 and 40 years (inclusive);
- Exhibit abnormal uterine peristalsis on transvaginal ultrasound performed on the morning of the scheduled blastocyst transfer, defined as either: high-frequency peristalsis (\>4 contractions per minute), or a negative wave pattern (fundus-to-cervix direction) at any frequency.
- Each woman could only participate in one transfer cycle.
- Exclusion criteria
- Immunologic or endocrine disorders including thyroid dysfunction, antiphospholipid syndrome, hyperprolactinemia and other severe systematic diseases (e.g., hypertension, diabetes, etc.)
- Uterine malformations (e.g., intrauterine adhesions; unicornuate, bicornuate or septate uterus)；
- Untreated hydrosalpinx or endometrial polyp；
- Cycles that included in-vitro maturation or oocyte donation；
- Prior participation in Atosiban 1 study；
- Current participation in any other clinical trial；
- Inability to provide informed consent to the study.
Exclusion
Key Trial Info
Start Date :
December 6 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2027
Estimated Enrollment :
792 Patients enrolled
Trial Details
Trial ID
NCT07185230
Start Date
December 6 2025
End Date
September 30 2027
Last Update
December 9 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Center for Reproductive Medicine, Northwest Women's and Children's Hospital
Xi'an, Shaanxi, China, 710003