Status:
COMPLETED
Respiratory Safety of Oliceridine During Sedated Gastrointestinal Endoscopy
Lead Sponsor:
Shiyou Wei
Conditions:
Hypoxemia During Surgery
Gastrointestinal Endoscopy
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
This study is a prospective, single-center, double-blind, randomized controlled trial designed to evaluate the effect of oliceridine versus sufentanil on the incidence of hypoxemia in adult patients u...
Detailed Description
Gastrointestinal endoscopy is frequently performed under deep sedation to minimize patient discomfort caused by mechanical stimulation. Currently, the combination of propofol and short-acting opioids,...
Eligibility Criteria
Inclusion
- Male or female patients aged ≥ 18 years.
- Scheduled to undergo elective gastrointestinal endoscopy (gastroscopy or colonoscopy).
- American Society of Anesthesiologists (ASA) physical status I-III.
- No history of severe cardiopulmonary dysfunction or other major systemic disease.
Exclusion
- Dementia or any cognitive impairment precluding provision of informed consent.
- Known contraindication to oliceridine.
- Chronic (long-term) opioid use.
- Any other medical or logistic condition that, in the investigator's judgment, makes the participant unsuitable for the study (specify reason).
Key Trial Info
Start Date :
September 22 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2025
Estimated Enrollment :
508 Patients enrolled
Trial Details
Trial ID
NCT07187765
Start Date
September 22 2025
End Date
December 1 2025
Last Update
January 5 2026
Active Locations (1)
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1
Tianmen First People's Hospital
Tianmen, Hubei, China, 431700