Status:
COMPLETED
Diastolic Dysfunction 2025
Lead Sponsor:
University Tunis El Manar
Conditions:
Preeclampsia
Severe Preeclampsia
Eligibility:
FEMALE
18-45 years
Brief Summary
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregna...
Detailed Description
Preeclampsia is a major hypertensive disorder of pregnancy associated with increased maternal morbidity and mortality, as well as long-term cardiovascular risk. Cardiac remodeling in this context is c...
Eligibility Criteria
Inclusion
- Pregnant women aged 18-45 years
- Third trimester of pregnancy
- Group A: women diagnosed with preeclampsia according to international criteria (blood pressure ≥ 140/90 mmHg after 20 weeks with proteinuria or signs of severity)
- Group B (controls): normotensive pregnant women without proteinuria or cardiovascular disease
- Signed informed consent
Exclusion
- Known pre-existing cardiovascular disease (structural heart disease, heart failure, chronic hypertension complicated)
- Left ventricular ejection fraction \< 45%
- Pre-gestational diabetes
- Chronic kidney disease
- Multiple pregnancy
- Other severe comorbidities that could affect cardiac function independently of preeclampsia
Key Trial Info
Start Date :
March 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 31 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07190846
Start Date
March 1 2025
End Date
July 31 2025
Last Update
September 24 2025
Active Locations (1)
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1
Maternity and Neonatology Center of Tunis
Tunis, Tunisia, 1007