Status:
ENROLLING_BY_INVITATION
Next-generation Sequencing Technology in the Clinical Application of Respiratory Specimens
Lead Sponsor:
Bin Zhang
Conditions:
Lung Infection
Eligibility:
All Genders
18+ years
Brief Summary
Obtain the performance parameters and clinical consistency of mNGS and tNGS technologies in the pathogen diagnosis of lower respiratory tract specimens from patients with severe pulmonary infections, ...
Detailed Description
Compared with pathogenic mNGS detection of lower respiratory tract airway secretion specimens, pathogenic tNGS detection can further shorten the detection time.It can more accurately analyze the patho...
Eligibility Criteria
Inclusion
- Voluntary signing of the informed consent form.
- Common respiratory infections: traditional methods cannot clearly identify and the patient's condition is prolonged without improvement; Patients with a high suspicion of viral pneumonia: such as acute onset during a season of high viral incidence, normal or low blood leukocyte counts, rapid disease progression, negative results for respiratory viral multiplex PCR testing and cultures; Immunocompromised patients: experiencing respiratory infections or severe illness.
- Sufficient samples can be obtained.
- Patients with complete clinical data.
Exclusion
- Refusal to sign informed consent.
- Testing has clearly excluded infection.
- Received antibiotic treatment within three days prior to testing without stopping the medication for more than 12 hours.
- Sample quality is not up to standard.
- Unable to obtain sufficient sample.
- No complete drug usage history.
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07191080
Start Date
October 1 2024
End Date
December 31 2027
Last Update
September 24 2025
Active Locations (1)
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1
Affiliated Hospital of Nantong University
Nantong, Jiangsu, China, 226006