Status:
NOT_YET_RECRUITING
Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed Interventions
Lead Sponsor:
Imperial College Healthcare NHS Trust
Collaborating Sponsors:
University of Leeds
Imperial College London
Conditions:
NEC - Necrotizing Enterocolitis
NEC
Eligibility:
All Genders
23-30 years
Brief Summary
MAGPIE-2 is a prospective observational study designed to investigate the physiological mechanisms linking blood transfusion and enteral feeding practices to gut perfusion and oxygenation in very pret...
Detailed Description
MAGPIE-2 is a mechanistic observational study nested within the WHEAT International randomised controlled trial, which compares two standard neonatal care practices: withholding versus continuing ente...
Eligibility Criteria
Inclusion
- Very preterm babies (born between 23 to \<30 weeks of gestational age ) in the WHEAT International trial
- Written informed consent from parents
Exclusion
- Babies who are deemed too unstable to perform the non-invasive monitoring and the ultrasound scan measurements by the attending clinical team
- Babies who have already developed Bells stage 2 NEC, had bowel surgery or congenital abdominal conditions such as congenital diaphragmatic hernia, gastroschisis and exomphalos
Key Trial Info
Start Date :
November 3 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2027
Estimated Enrollment :
270 Patients enrolled
Trial Details
Trial ID
NCT07191678
Start Date
November 3 2025
End Date
April 30 2027
Last Update
September 25 2025
Active Locations (1)
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1
Queen Charlotte's & Chelsea Hospital, Neontal Unit
London, United Kingdom, W12 0HS